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RheumaShield

RheumaShield Image

DESCRIPTION
RheumaShieldTM from Douglas Laboratories® contains 10 mg of native, undenatured type II collagen (UC IITM) from chicken sternum cartilage.
FUNCTIONS
UC·IITM is a patented form of undenatured type II collagen. Collagen is a fibrous protein secreted by connective tissue and is the prime structural component of skin, bones and joints. It represents close to 25% of all the body’s protein. Although about 15 types of collagen have been found in various parts of the body, the fibrillar type II collagen is distributed primarily in articular cartilage, i.e. cartilage associated with joints. UC·IITM is from cartilage that has been sterilized without substantially altering its chemical or molecular structure. This type of collage preparation has been shown to maintain the healthy structure and function of articular joints.
Studies have shown that oral administration of native, i.e. undenatured, type II collagen helps support joint health, by a mechanism known as oral tolerance. Oral tolerance is a state of anergy or hyporesponsiveness that follows the exogenous administration of antigen to the peripheral immune system via the gut. Animal studies have demonstrated the effectiveness of oral tolerance.
The size of the antigen dose determines the mechanism of oral tolerance. In response to a low oral dose of antigen, Peyer’s patches, gut specific lymphoid tissue specialized to respond to antigens entering the body from the intestine, are thought to activate regulatory T-cells to produce inhibitory cytokines, e.g. interleukin 4, interleukin 10 and transforming growth factor beta. Some of the activated T-cells may also migrate to the site of the joint and suppress, via their secreted cytokines, inducing T-helper cells (Th1), i.e. bystander suppression. Other studies have also suggested that oral antigen induction of interferon gamma may contribute to oral tolerance by decreasing T-cell migration to peripheral sites.
Clinical studies in humans suggest type II collagen may support healthy joint structure and function. RheumaShieldTM is a synergistic combination of UC IITM in a proprietary blend of Devil’s Claw and Bromelain formulated for optimum joint support.

RheumaShield

RheumaShield Image

DESCRIPTION
RheumaShieldTM from Douglas Laboratories® contains 10 mg of native, undenatured type II collagen (UC IITM) from chicken sternum cartilage.
FUNCTIONS
UC·IITM is a patented form of undenatured type II collagen. Collagen is a fibrous protein secreted by connective tissue and is the prime structural component of skin, bones and joints. It represents close to 25% of all the body’s protein. Although about 15 types of collagen have been found in various parts of the body, the fibrillar type II collagen is distributed primarily in articular cartilage, i.e. cartilage associated with joints. UC·IITM is from cartilage that has been sterilized without substantially altering its chemical or molecular structure. This type of collage preparation has been shown to maintain the healthy structure and function of articular joints.
Studies have shown that oral administration of native, i.e. undenatured, type II collagen helps support joint health, by a mechanism known as oral tolerance. Oral tolerance is a state of anergy or hyporesponsiveness that follows the exogenous administration of antigen to the peripheral immune system via the gut. Animal studies have demonstrated the effectiveness of oral tolerance.
The size of the antigen dose determines the mechanism of oral tolerance. In response to a low oral dose of antigen, Peyer’s patches, gut specific lymphoid tissue specialized to respond to antigens entering the body from the intestine, are thought to activate regulatory T-cells to produce inhibitory cytokines, e.g. interleukin 4, interleukin 10 and transforming growth factor beta. Some of the activated T-cells may also migrate to the site of the joint and suppress, via their secreted cytokines, inducing T-helper cells (Th1), i.e. bystander suppression. Other studies have also suggested that oral antigen induction of interferon gamma may contribute to oral tolerance by decreasing T-cell migration to peripheral sites.
Clinical studies in humans suggest type II collagen may support healthy joint structure and function. RheumaShieldTM is a synergistic combination of UC IITM in a proprietary blend of Devil’s Claw and Bromelain formulated for optimum joint support.